Br J Dermatol. 1997 Nov;137(5):699-702.
A controlled study of the effects of RU58841, a non-steroidal antiandrogen, on human hair production by balding scalp grafts maintained on testosterone-conditioned nude mice. De Brouwer B, Tetelin C, Leroy T, Bonfils A, Van Neste D. (Skin Study Centre, Tournai, Belgium, France.)


"Human hair growth can be monitored for several months after the transplantation of scalp samples from men with androgen-dependent alopecia on to female nude mice. Hair production from balding sites has been shown to be inhibited in testosterone-conditioned nude mice. We used this recently reported model to study the effect of a new non-steroidal antiandrogen-RU58841-on human hair growth. Twenty productive scalp grafts from balding men were maintained for 8 months after grafting on to nude mice, and hair production was monitored monthly for 6 months. All mice were conditioned by the topical application of testosterone (testosterone propionate, 300 micrograms in 10 microL; 5 days/week) on the non-grafted flank. The scalp samples were divided equally according to the estimated hair production potential, which was based on the amount of hair present on the scalp samples before grafting. Each of the two equal groups of grafts was further allocated at random to be treated topically (5 days/week) with blinded solutions of either RU58841 1% in ethanol, or ethanol as a control. Twenty-eight active follicles appeared on the 10 control grafts. Among them only two follicles (7%) initiated a second hair cycle. However, the 10 RU58841-treated grafts bore a total of 29 active follicles, and eight of them (28%) showed a second cycle. The values for the linear hair growth rates (LHGR) were significantly (P < 0.04) higher in the RU58841-treated group. Recycling and increased LHGR indicate a positive action for RU58841 on human hair growth from balding samples grafted on to testosterone-conditioned nude mice, and encourage a clinical trial to evaluate its potential in the treatment of androgen-dependent alopecia."

FRESH is the answer. I just got a fresh batch of RU after first talking to faitheagle about my concerns of lack of freshness. This new batch is showing very good signs after just a few days. I was on an earlier batch and it was mediocre...weaker than I was used to. This new batch is kickass. It is like it is in high gear or something.

This is the only way to go...we need to get this stuff FRESH. That is the answer. But they will only make a kilo or more so we can not get small amounts made up fresh. If you want small amounts you will have to settle for the leftover from a previous large batch.

The only logical answer is that we all need to get on a system/program of ordering FRESH RU every 3 months. If we do it together we can each buy 20 - 30 grams and together it will be a kilo and we can keep doing this every 3 months and that way we will each always have fresh RU. This is the answer to our problems and we need to form a group of us to do this on a continual basis every 3 months. It will take maybe 40 or 50 of us.

I am very happy with this batch I just got because there are signs it is working. The last batch I had was giving iffy evidence it was working and I couldn't really say it was working for sure. This batch seems much more certain.

We need to get on a schedule of us all getting together and getting FRESH RU every 3 months. The only way we can get a kilo fresh every 3 months is to join forces.

FRESH RU is looking like the answer to me. I'm very excited by what is happening on my head right now.

My email address is: maneless@hotmail.com

התקבלה תגובה חדשה להודעתך בפורום באתר דוקטורס, אתר הבריאות לקהל הרחב.

להלן התגובה:

RE: שלום יש לי שאלה חשובה אשמח על תשובה כנה

מחבר: ד"ר פנינה שמש
תאריך: 12.8.2006
שעה: 17:00
לשאלתך, פרופציה היא תרופת מרשם המיוצרת על חברה מסויימת המוגנת על ידי פטנט. אין חברה נוספת המייצרת כעת תרופה זו. בעתיד כשהפטנט יצא מתוקף, ייתכן ויהיו חברות נוספות שייצרו את התרופה ואז היא אולי תהיה יותר זולה.
אני לא מציעה לרכוש את התרופה באופן פירטי.
לגבי החומר RU, הוא אנטי אנדרוגן שנמצא יעיל בינתיים רק בנסיונות על חיות ועדיין יש לחכות לפיתוח של תרופה המתאימה לבני אדם וגם לא מזיקה. שוב, לא מציעה לנסות תרופה באופן פירטי, מדובר בבריאותכם תשמשו רק בתרופות המומלצות ונרשמות על ידי רופא.

Nova Biosciences, Norrie Point Research Station, Staatsburg, New York 12553, USA.

The biological activity of a series of nonsteroidal, pure androgen receptor inhibitors was compared using the Syrian hamster ear skin sebaceous gland model. RU 58841, RU 56187, RU 38882 and cyproterone acetate were applied topically for 4 weeks on the ventral ear pinna of sexually mature male Syrian hamsters. Their order of efficacy was as follows: RU 58841 > RU 56187 > RU 38882 > cyproterone acetate. Maximal reduction of 60% in the size of the sebaceous glands was observed in hamsters treated with RU 58841 at a dose of 10 micrograms per day. This degree of inhibition occurred without any systemic side effects as shown by the absence of inhibition on the contralateral untreated ear pinna. Longer treatment did not produce greater inhibition since extending the treatment period from 4 weeks to 12 weeks showed similar data. The effect of RU 58841 was reversible since the inhibited sebaceous glands returned to normal size within 4 weeks after the cessation of the topical applications. The potent localized inhibition of sebaceous glands by RU 58841 demonstrates the excellent potential of this compound as a topical drug for the treatment of acne and other androgen-mediated disorders

מתי לדעתך נוכל לקנות את התרופה הזאת בארץ... ואיך זה שהיא כבר 10 שנים קייימת ואין לה מודעות?
זה נחשב לטיפול הכי חזק להתקרחות היום?