Similar to the proliferation index, the MVD of primary tumors in all treated groups were reduced by 56–69% compared with the control (Fig. 2 B). No apparent synergistic effects between SPC and tea on tumor angiogenesis were observed. The treatments did not affect the tumor cell apoptotic index (data not shown).
Combined effects of soy phytochemicals and tea on serum testosterone and DHT concentrations.

Mice treated with black tea tended to have a greater serum testosterone concentration (34.4%, P = 0.50) and had a 72% lower DHT concentration than controls (P < 0.05), suggesting that black tea may contain components that inhibit the activity of 5-reductase, an enzyme that converts testosterone to the more bioactive DHT. Green tea tended to increase serum testosterone and DHT levels by 73.8% (P = 0.14) and 194% (P = 0.076), respectively. The combination of SPC and green tea reduced serum levels of DHT (P < 0.05).