זוהר אני חושב שזה יעניין במיוחד אותך
http://www.hair2004.com/download/HairAb ... eil_II.pdf
Methods:
Blood Cell DNA was extracted from 740 MPB patients (age 19 to 62) and 54 men who were not losing their hair (age 44 to 72). After PCR of the first exon of their Androgen Receptor gene, the number of CAG and GGC triplets was determined by conventional sequencing or transcriptional sequencing method. AGGCCT sequence was determined using two different Stul restriction enzymes.
Results and Conclusions:
Effectiveness of Finasteride in each patient was defined as showing improvement on the Norwood scale. Number of the triplet repeats (CAG+GGC) was plotted against the symptom points. There was a broad correlation between these variables.
Finasteride was more effective for patients who had shorter triplet regions of the androgen receptor gene. Therefore hair loss may be caused by a hyper-function of the androgen receptors in these people. On the other hand, Finasteride was LESS effective when we found longer triplet repeats. These people may be losing their hair due to a non-androgenic related mechanism. This sort of analysis may help people choose what treatment to use for their Male Pattern Baldness.
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בקצרה ,
המחקר בוצע על פיינסטרייד וקובע כי ישנם אנשים בעלי רצפטורים יותר "יעילים" ,
כלומר בעלי קליטה טובה יותר של ה-DHT ,
ומכאן נובעים ההבדלים בהשפעת טיפולים המורידים DHT בין אנשים שונים.
